The Friday evening 1715 London Euston to Glasgow service derailed on the section of West Coast Main Line near Tebay near Lake District. Total number of injuries yet know due to remote of the site. Rescue operation are currently underway, with assistance from Royal Air Force.
A passenger has died and dozens have been injured after a train derailed and some of its carriages slid down an embankment in Cumbria.
Ambulance crews said three were in a critical condition in hospital.
Nine carriages were left on their side after the crash at Grayrigg near Kendal, with passengers saying some were left "stuck up in the air".
The Virgin train, the 1715 from London Euston due to arrive at Glasgow Central at 2154 GMT, crashed at 2015 GMT.
Neither Virgin nor Network Rail have yet been able to say what might have caused the crash.
All but one of the train's carriages had totally come off the tracks, a Cumbria Ambulance Service spokeswoman said.
Passengers coming off the train were assessed on the scene and any minor injuries would be treated there if possible, she added.
One of the passengers, BBC executive Caroline Thomson, said the train "did a sort of bump - and I was thinking don't worry this fine - but then the swaying became very dramatic.
"It suddenly appeared to hit something and then lurched very, very badly from side to side in a very dramatic way. This a very scary experience."
The Pendolino tilting trains have been introduced by Virgin over the last three years and have a top speed of 125 mph.
Network Rail said the line speed for the area where the crash took place was about 95 mph.
Virgin services between Preston and Carlisle have been suspended until further notice and alternative arrangements for customers, using road vehicles, are being made.
All Scotrail sleeper services to London have also been cancelled, with passengers being transferred to coach services.
Rail expert Christian Wolmar said it was too early to speculate on the cause of the crash, but he said that a broken rail would be one possibility.
"It could also be that the train was going too fast or it could be some other kind of mechanical failure. It could even have been an obstruction on the line," Mr Wolmar said.
"Virgin has a good safety record as does the railways [as a whole]."
In-built safety features included crumple zones at the front of the train, safety exits and ladders, he added.
"They have a very high standard of resistance to accidents but one has to recognise that they go very fast and that nothing can prevent some damage happening when accidents happen at that speed."
今次好有可能同 Network Rail 公司有關，至於係咪同最近 West Coast Mainline既工程有關，就要遲d先有報告。
Crash inquiry to focus on points
The inquiry into the Cumbria rail crash in which one person died will focus on a set of points, investigators say.
Bob Crow, general secretary of the Rail Maritime and Transport Union, said the inquiry must be allowed to find out the full facts of what happened.
But he added: "If points failure is the cause there must be a robust investigation into the management system's failings that led to it and there must be no attempt simply to scapegoat staff."
Up to 700 sets of points across the entire rail network are to be checked as a "precaution" following the Cumbria crash, Network Rail has said.
Investigators earlier said the accident, in which a woman died, could have been caused by a points failure.
Experts are focusing on one set that the Virgin Trains Pendolino ran across before derailing near Kendal.
Rail expert Christian Wolmar told the BBC that the points could have been defective with loose nuts and bolts.
Network Rail said engineers had already started the nationwide safety checks of between 600 and 700 sets of points.
The checks are to be carried out on high-speed rail lines on older tracks where trains travel above 85 miles per hour.
Network Rail, which is responsible for maintaining track, hopes to complete the checks within the next 24 hours.
Christian Wolmar told BBC News 24 he understood the circumstances were thought to be similar to those in the Potters Bar crash.
In that crash, in May 2002, seven people died and 76 were injured when poorly maintained points derailed a train.
"From what I understand, they have found these points in a similar condition to those at Potters Bar, with some missing nuts and the stretcher bar which keeps the rails properly apart apparently loosened," he said.
Mr Wolmar said it was up to Network Rail to ensure that the points were properly maintained and that "things like loose bolts, loose bolts and nuts, were tightened up regularly".
He added: "But there is also the possibility that these nuts and bolts were maintained in the wrong way, or not sufficiently maintained, and that's why they were in that condition."
The chief executive of Network Rail, John Armitt, acknowledged that there might have been a points failure. He said the points were last serviced earlier this month, and that track maintenance was carried out by Network Rail employees.
Sir Richard said the strength of the Pendolino train had helped to limit the number of casualties.
"The train itself was magnificent - it's built like a tank.
"I think if it had been any of the old trains the injuries and the mortalities would have been horrendous.
"And each carriage is built like a motor racing car with rolling bars. Not one of the carriages has crumpled, hardly any of the windows have been broken."
He told reporters he had been told that points were to blame for the accident, but he did not know how they had failed.
"Everyone is going to have to learn from this incident and Network Rail are going to have to look at this track problem and make sure nothing like this ever happens again."
Pendolino係硬淨過英製列車，連Sir Richard都係咁講: